1993年 Max-Planck-Institut for Immunbiologie, Dr. Manfred Kopfらにより開発。D3 ES細胞由来。東大医科研岩倉研でBALB/cAに7世代戻し交配 (BRC寄託時)。129S2/SvPas (D3) C;129S2-Il4<tm1Kopf> C;129S2-Il4<tm1Kopf> 岩倉 洋一郎 IL-4遺伝子欠損マウス。寄生虫感染に対して易感染性。 Immunology and Inflammation Research Yoichiro IWAKURA BALB/cA (亜系統は不明) C.129S2-Il4<tm1Kopf> D (more than 6 months) D(6か月以上) 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 362(6417):245-248 (1993).<br>研究成果の公表にあたって謝辞の表明を必要とする。 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1993. The mice were backcrossed to BALB/c for at least 7 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 362(6417):245-248 (1993).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 1993年 Max-Planck-Institut for Immunbiologie, Dr. Manfred Kopfらにより開発。 D3 ES細胞由来。 東大医科研岩倉研でBALB/cAに7世代戻し交配 (BRC寄託時)。 129S2/SvPas (D3) herpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il4 genomic DNA true IL-4 knockout mice. Homozygous mutant mice show increased susceptibility to parasitic infection. BALB-Il4 KO RBRC04921